Course Outline (W2020)

BME423: Biomaterials

Instructor(s)Muhammad Hasibul Hasan [Coordinator]
Office: EPH 312 E
Phone: TBA
Email: hasibulhasan@ryerson.ca
Office Hours: TBA
Calendar DescriptionThe principles of materials science and engineering with particular attention to topics most relevant to biomedical engineering. The structure-property relationships of metals, ceramics, polymers, and composites as well as skin, bone, cartilage, ligament, and vasculature; extensive treatment of the properties unique to materials' surfaces. Behavior of materials in the physiological environment.
PrerequisitesBLG143 and BME323




Compulsory Text(s):
  1. Please obtain the BME423 laboratory manual from the Ryerson bookstore before attending your first lab.
Reference Text(s):
  1. Biomaterials: An Introduction, J. Park and R.S. Lakes, Springer, 2007
  2. Biomaterials: A Basic Introduction, Q. Chen and G. Thouas – CRC Press, 2016
  3. Advanced Biomaterials: Fundamentals, Processing, and Applications, B. Basu, D.S. Katti and A. Kumar - John Wiley and Sons 2009
  4. Introduction to Dental Materials - 3rd Edition R. van Noort - Mosby, 2008
  5. An Introduction to tissue-Biomaterial Interactions, K.C. Dee, D.A. Puleo and R. Bizios - John Wiley and Sons, 2002
  6. Introduction to Biomedical Engineering - 2nd Edition M.M. Domach - Pearson/Prentice Hall, 2009
Learning Objectives (Indicators)  

At the end of this course, the successful student will be able to:

  1. Apply a basic knowledge of science, conduct experiments on science principles and interpret the obtained results, develop further knowledge of science in support of application to engineering problems. (1a)
  2. Interpret the results both qualitatively and quantitatively and check conclusions against objectives. (2a)
  3. Make valid assumptions based on available information. (2b)
  4. Make accurate use of technical literature and other information sources, determine the data that are appropriate to collect. recognize the characteristics of, and distinguish between experimental and investigations and theory. (3a)
  5. Interpret experimental data using scientific technique and analysis. (5a)
  6. Develop the understanding of the regulatory body and they shared responsibility for sustainable development (9a)
  7. Source and Use up to date information for evaluation. (12a)

NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB).

Course Organization

3.0 hours of lecture per week for 13 weeks
2.0 hours of lab/tutorial per week for 12 weeks

Teaching AssistantsTBA
Course Evaluation
Midterm test 20 %
Final Examination 60 %
Assignments 10 %
Practicum 10 %
TOTAL:100 %

Note: In order for a student to pass a course with "Theory and Laboratory" components, in addition to earning a minimum overall course mark of 50%, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section for details on the Theory and Laboratory components.

ExaminationsDuring exam period, 3 hours, closed-book (covers weeks 1-13)
Other Evaluation InformationNote: In order to pass the course, a student must: (1) achieve an overall score for the course of 50% or higher AND (2) obtain a passing grade (ie 40/80) on the combined midterm test and final examination.
 All of the required course-specific written reports/assignments/labs will be assessed not only on their technical/academic merit, but also on the communication skills exhibited through them.
Other InformationCOURSE LEARNING OUTCOMES: When students successfully complete this course they will understand the concepts behind developing medical materials and processes, the accreditation procedures that are used to ensure device and process safety and efficacy and how these procedures are applied using laboratory and clinical techniques.
 TOPICS COVERED: (1) history of medical and dental science, (2) bacteria, (3) medical devices, (4) medical processes, (5) tissue engineering, (6) introduction to FDA accreditation.

Course Content



Chapters /

Topic, description



Introduction to biomaterials, biological response to biomaterials, types of biomaterials, processing of biomaterials, biomaterial product testing, important properties of biomaterials, principles of chemistry including atomic structure and bonding.
 Chemical structure of biomaterials: crystal structure, point defect and diffusion of metals, structure and point defect of ceramics, structure and synthesis of polymers, methods of polymerization, copolymer, material characterization techniques, X-ray diffraction.
 Physical properties of biomaterials: crystallinity, linear, planar and volume defects, polymer crystallinity, thermal transitions of crystalline and non-crystalline materials, thermal analysis techniques, differential scanning calorimetry.



Mid-Term Test



Mechanical properties of biomaterials: mechanical testing modes methods results and calculations hardness impact tests fracture fatigue methods to improve mechanical properties mechanical analysis techniques.
 Degradation of biomaterials: corrosion/degradation of metals and ceramics fundamentals of electrochemistry and corrosion contributions of processing parameters mechanical and biological environments means of corrosion control degradation of polymers biodegradable materials.
 Surface properties of biomaterials: concepts in surface chemistry and biology physicochemical surface modification techniques biological surface modification techniques surface properties and degradation patterning techniques for surfaces.
 Polymer composite materials cortical bone and trabecular bone skin cartilage ligament and vaculature.

Laboratory/Tutorials/Activity Schedule





Lab 1

Construction of atomic models


Lab 2

Identification of materials by X-ray diffraction


Lab 3

Corrosion experiments of materials


Lab 4

Impact and hardness testing


Lab 5

Tensile properties of polymeric materials.

Policies & Important Information:

  1. Students are required to obtain and maintain a Ryerson e-mail account for timely communications between the instructor and the students;
  2. Any changes in the course outline, test dates, marking or evaluation will be discussed in class prior to being implemented;
  3. Assignments, projects, reports and other deadline-bound course assessment components handed in past the due date will receive a mark of ZERO, unless otherwise stated. Marking information will be made available at the time when such course assessment components are announced.
  4. Refer to our Departmental FAQ page for information on common questions and issues at the following link: https://www.ee.ryerson.ca/guides/Student.Academic.FAQ.html.

Missed Classes and/or Evaluations

When possible, students are required to inform their instructors of any situation which arises during the semester which may have an adverse effect upon their academic performance, and must request any consideration and accommodation according to the relevant policies as far in advance as possible. Failure to do so may jeopardize any academic appeals.

  1. Health certificates - If a student misses the deadline for submitting an assignment, or the date of an exam or other evaluation component for health reasons, they should notify their instructor as soon as possible, and submit a Ryerson Student Health Certificate AND an Academic Consideration Request form within 3 working days of the missed date. Both documents are available at https://www.ryerson.ca/senate/forms/medical.pdf.. If you are a full-time or part-time degree student, then you submit your forms to your own program department or school;
  2. Religious, Aboriginal and Spiritual observance - If a student needs accommodation because of religious, Aboriginal or spiritual observance, they must submit a Request for Accommodation of Student Religious, Aboriginal and Spiritual Observance AND an Academic Consideration Request form within the first 2 weeks of the class or, for a final examination, within 2 weeks of the posting of the examination schedule. If the requested absence occurs within the first 2 weeks of classes, or the dates are not known well in advance as they are linked to other conditions, these forms should be submitted with as much lead time as possible in advance of the absence. Both documents are available at www.ryerson.ca/senate/forms/relobservforminstr.pdf. If you are a full-time or part-time degree student, then you submit the forms to your own program department or school;
  3. Academic Accommodation Support - Before the first graded work is due, students registered with the Academic Accommodation Support office (AAS - www.ryerson.ca/studentlearningsupport/academic-accommodation-support) should provide their instructors with an Academic Accommodation letter that describes their academic accommodation plan.

Academic Integrity

Ryerson's Policy 60 (the Academic Integrity policy) applies to all students at the University. Forms of academic misconduct include plagiarism, cheating, supplying false information to the University, and other acts. The most common form of academic misconduct is plagiarism - a serious academic offence, with potentially severe penalties and other consequences. It is expected, therefore, that all examinations and work submitted for evaluation and course credit will be the product of each student's individual effort (or an authorized group of students). Submitting the same work for credit to more than one course, without instructor approval, can also be considered a form of plagiarism.

Suspicions of academic misconduct may be referred to the Academic Integrity Office (AIO). Students who are found to have committed academic misconduct will have a Disciplinary Notation (DN) placed on their academic record (not on their transcript) and will normally be assigned one or more of the following penalties:

  1. A grade reduction for the work, ranging up to an including a zero on the work (minimum penalty for graduate work is a zero on the work);
  2. A grade reduction in the course greater than a zero on the work. (Note that this penalty can only be applied to course components worth 10% or less, and any additional penalty cannot exceed 10% of the final course grade. Students must be given prior notice that such a penalty will be assigned (e.g. in the course outline or on the assignment handout);
  3. An F in the course;
  4. More serious penalties up to and including expulsion from the University.

The unauthorized use of intellectual property of others, including your professor, for distribution, sale, or profit is expressly prohibited, in accordance with Policy 60 (Sections 2.8 and 2.10). Intellectual property includes, but is not limited to:

  1. Slides
  2. Lecture notes
  3. Presentation materials used in and outside of class
  4. Lab manuals
  5. Course packs
  6. Exams

For more detailed information on these issues, please refer to the Academic Integrity policy(https://www.ryerson.ca/senate/policies/pol60.pdf) and to the Academic Integrity Office website (https://www.ryerson.ca/academicintegrity/).

Important Resources Available at Ryerson

  1. The Library (https://library.ryerson.ca/) provides research workshops and individual assistance. Inquire at the Reference Desk on the second floor of the library, or go to library.ryerson.ca/guides/workshops
  2. Student Learning Support(https://www.ryerson.ca/studentlearningsupport) offers group-based and individual help with writing, math, study skills and transition support, and other issues.