Course Outline (F2019)

BME703: Tissue Engineering

Instructor(s)Loraine Chiu [Coordinator]
Office: TBA
Phone: TBA
Email: loraine.chiu@ryerson.ca
Office Hours: TBA
Calendar DescriptionTissue engineering approach for augmentation or replacement of compromised tissue function in nerve, microvessels, skin and cartilage. Integrative exploration of the use of three-dimensional polymeric scaffolds and drug delivery vehicles, and gene therapy and cellular engineering for functional repair of injured tissues.
PrerequisitesBLG 601 and BLG 701




Compulsory Text(s):
  1. Tissue Engineering, Bernhard Ø. Palsson, Sangeeta N. Bhatia, Pearson Prentice Hall, New Jersey, 2004
Reference Text(s):
Learning Objectives (Indicators)  

At the end of this course, the successful student will be able to:

  1. Develops further knowledge of science in support of application to engineering problems. (1a)
  2. Demonstrates and applies core engineering principles and concepts to solve engineering. Demonstrates, integrates, and applies specialized sub-disciplines and/or interdisciplinary engineering principles to systems or processes. (1c)
  3. Evaluates sources of information, checks the feasibility of design based on the obtained results, and assesses the reliability of conclusions. (2a)
  4. Constructs hypothesis or problem statement consistent with the information available and the constraints/parameters of the problem. (3b)
  5. Applies mathematical and scientific principles to predict behavior of systems or processes. (3a)
  6. Uses technical knowledge, design methodology, and appropriate design tools and related resources. (4a)
  7. Analyze data to make decisions. (5b)
  8. Assesses ethical risks and evaluates situations and actions in terms of the professional code of ethics for engineers. (10a)

NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB).

Course Organization

3.0 hours of lecture per week for 13 weeks
1.0 hours of lab/tutorial per week for 12 weeks

Teaching AssistantsMs. Arianna Soave
 Mr. Roberto Tarantino
 Ms. Aisha Momin
Course Evaluation
Labs 30 %
Midterm Exam 30 %
Final Exam 40 %
TOTAL:100 %

Note: In order for a student to pass a course with "Theory and Laboratory" components, in addition to earning a minimum overall course mark of 50%, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section for details on the Theory and Laboratory components.

ExaminationsMidterm exam in Week 7, two hours, closed book (covers Weeks 1-6)
 Final exam, during exam period, three hours, closed-book (covers Weeks 1-13).
Other Evaluation InformationImportant Notes:
 Attendance in all classes, tutorials and labs are required. In particular, students are expected actively participate in labs and tutorials. Taking proper notes of lectures and tutorials are advised.
 Labs and Reports
 (a) Labs will be held in Biology/Microbiology Lab., KHE 313/315 bi-weekly.
     The detail information can be gathered in BME 703 Tissue Engineering
     Laboratory Manual.
 (b) A student absent in any lab will need to provide valid reasons for the
     absence along with supporting official documents.
 (c) All lab reports must have the standard cover page which can be
     completed and printed from the Department website at:
 The cover page must be signed by the student(s) prior to the submission of the work. The submission of assignment and reports should be organized in the following order:
    i. Cover page
   ii. Question sheet
  iii. Students’ solution (for homework assignments) and lab results (for
       lab reports).
 Please note that submissions without the cover pages will NOT be accepted.
 Late Submissions
 Any late submission of laboratory report is outlined in BME 703 Tissue Engineering Laboratory Manual. Any late submission of homework assignment (without justifiable reasons and advanced notice to the instructor/TA) will result in a mark deduction as below:
    a. 1 day: 25% deduction
    b. 2 days: 50% deduction
    c. 3 days: unacceptable
Other InformationNone

Course Content



Chapters /

Topic, description




Introduction to Tissue Engineering



Chapter 1 Sections 1.1-1.3 and Notes

Cellular Therapies



Chapter 2 Sections 2.1-2.3 and Notes

Tissue Organization



Chapters 3,4 Sections 3.1-3.3, 4.1-4.3 and Notes

Tissue Dynamics and Morphogenesis



Chapter 5 Sections 5.1-5.3 and Notes

Stem Cells



Chapters 6,7 Sections 6.1-6.5, 7.1-7.4 and Notes

Cellular Fate Processes



Chapter 10 Sections 10.1-10.7 and Notes

Cell and Tissue Culture



Chapter 11 Sections 11.1-11.4 and Notes

Gene Transfer



Chapter 13 Sections 13.1-13.5 and Notes

Scaling Up for Ex Vivo Cultivation

Laboratory/Tutorials/Activity Schedule





Tutorial 1

Preparation and Biosafety


Lab 1

The Microscope


Tutorial 2

Preparation and Technical Writing for Engineers


Lab 2



Tutorial 3

Preparation and Biostatistics


Lab 3



Tutorial 4

Preparation and Aseptic and Sterile Techniques


Lab 4



Tutorial 5

Preparation and Instrumentation


Lab 5

Growth of Cells

Policies & Important Information:

  1. Students are required to obtain and maintain a Ryerson e-mail account for timely communications between the instructor and the students;
  2. Any changes in the course outline, test dates, marking or evaluation will be discussed in class prior to being implemented;
  3. Assignments, projects, reports and other deadline-bound course assessment components handed in past the due date will receive a mark of ZERO, unless otherwise stated. Marking information will be made available at the time when such course assessment components are announced.
  4. Refer to our Departmental FAQ page for information on common questions and issues at the following link: https://www.ee.ryerson.ca/guides/Student.Academic.FAQ.html.

Missed Classes and/or Evaluations

When possible, students are required to inform their instructors of any situation which arises during the semester which may have an adverse effect upon their academic performance, and must request any consideration and accommodation according to the relevant policies as far in advance as possible. Failure to do so may jeopardize any academic appeals.

  1. Health certificates - If a student misses the deadline for submitting an assignment, or the date of an exam or other evaluation component for health reasons, they should notify their instructor as soon as possible, and submit a Ryerson Student Health Certificate AND an Academic Consideration Request form within 3 working days of the missed date. Both documents are available at https://www.ryerson.ca/senate/forms/medical.pdf.. If you are a full-time or part-time degree student, then you submit your forms to your own program department or school;
  2. Religious, Aboriginal and Spiritual observance - If a student needs accommodation because of religious, Aboriginal or spiritual observance, they must submit a Request for Accommodation of Student Religious, Aboriginal and Spiritual Observance AND an Academic Consideration Request form within the first 2 weeks of the class or, for a final examination, within 2 weeks of the posting of the examination schedule. If the requested absence occurs within the first 2 weeks of classes, or the dates are not known well in advance as they are linked to other conditions, these forms should be submitted with as much lead time as possible in advance of the absence. Both documents are available at www.ryerson.ca/senate/forms/relobservforminstr.pdf. If you are a full-time or part-time degree student, then you submit the forms to your own program department or school;
  3. Academic Accommodation Support - Before the first graded work is due, students registered with the Academic Accommodation Support office (AAS - www.ryerson.ca/studentlearningsupport/academic-accommodation-support) should provide their instructors with an Academic Accommodation letter that describes their academic accommodation plan.

Academic Integrity

Ryerson's Policy 60 (the Academic Integrity policy) applies to all students at the University. Forms of academic misconduct include plagiarism, cheating, supplying false information to the University, and other acts. The most common form of academic misconduct is plagiarism - a serious academic offence, with potentially severe penalties and other consequences. It is expected, therefore, that all examinations and work submitted for evaluation and course credit will be the product of each student's individual effort (or an authorized group of students). Submitting the same work for credit to more than one course, without instructor approval, can also be considered a form of plagiarism.

Suspicions of academic misconduct may be referred to the Academic Integrity Office (AIO). Students who are found to have committed academic misconduct will have a Disciplinary Notation (DN) placed on their academic record (not on their transcript) and will normally be assigned one or more of the following penalties:

  1. A grade reduction for the work, ranging up to an including a zero on the work (minimum penalty for graduate work is a zero on the work);
  2. A grade reduction in the course greater than a zero on the work. (Note that this penalty can only be applied to course components worth 10% or less, and any additional penalty cannot exceed 10% of the final course grade. Students must be given prior notice that such a penalty will be assigned (e.g. in the course outline or on the assignment handout);
  3. An F in the course;
  4. More serious penalties up to and including expulsion from the University.

The unauthorized use of intellectual property of others, including your professor, for distribution, sale, or profit is expressly prohibited, in accordance with Policy 60 (Sections 2.8 and 2.10). Intellectual property includes, but is not limited to:

  1. Slides
  2. Lecture notes
  3. Presentation materials used in and outside of class
  4. Lab manuals
  5. Course packs
  6. Exams

For more detailed information on these issues, please refer to the Academic Integrity policy(https://www.ryerson.ca/senate/policies/pol60.pdf) and to the Academic Integrity Office website (https://www.ryerson.ca/academicintegrity/).

Important Resources Available at Ryerson

  1. The Library (https://library.ryerson.ca/) provides research workshops and individual assistance. Inquire at the Reference Desk on the second floor of the library, or go to library.ryerson.ca/guides/workshops
  2. Student Learning Support(https://www.ryerson.ca/studentlearningsupport) offers group-based and individual help with writing, math, study skills and transition support, and other issues.