| Instructor(s) | Dr. Dafna Sussman [Coordinator] Office: Phone: (416) 979-5000 x 553767 Email: dafna.sussman@torontomu.ca Office Hours: Monday 12-1pm By appointment | ||||||||||||||||
| Calendar Description | Mathematical modeling of biomedical systems. Lumped and distributed models of electrical, mechanical, and chemical processes applied to cells, tissues, and organ systems. | ||||||||||||||||
| Prerequisites | BLG 601 and BLG 701 and BME 229 and BME 639 | ||||||||||||||||
| Antirequisites | None | ||||||||||||||||
| Corerequisites | None | ||||||||||||||||
| Compulsory Text(s): |
| ||||||||||||||||
| Reference Text(s): |
| ||||||||||||||||
| Learning Objectives (Indicators) | At the end of this course, the successful student will be able to:
NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB). | ||||||||||||||||
| Course Organization | 3.0 hours of lecture per week for 13 weeks | ||||||||||||||||
| Teaching Assistants | TBA | ||||||||||||||||
| Course Evaluation |
Note: In order for a student to pass a course, a minimum overall course mark of 50% must be obtained. In addition, for courses that have both "Theory and Laboratory" components, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section above for details on the Theory and Laboratory components (if applicable). | ||||||||||||||||
| Examinations | Midterm Exam: The midterm exam will be in week 9 of the course (on March 11th). It will be a 2-hour, closed book test that will cover material from weeks 1-8. Quizzes: In week 7 (week of Feb. 26th) and week 11 (week of March 25th) of the course, will be of 30 minute duration at the start of tutorials 2 and 3, respectively. Quizzes are closed book and will cover lecture material from the previous 2-4 weeks. The final exam will be during the exam period, and will be 3 hours, closed book, and will cover all course material. | ||||||||||||||||
| Other Evaluation Information | Laboratory manuals will be posted on the course shell on D2L. The lab will run every week beginning week 2. All labs will involve simulating and/or processing physiological signals and systems using Matlab and/or Simulink software. Each lab is worth 5%, and will be marked based on completion of the lab report and answering TA questions during and at the end of the lab session. A lab report must be submitted for each of the four labs, one lab report per group, submitted within 1 week of completing the lab (emailed to the TA before the start of the next lab). Late submissions will be penalized over the first 3 days, after which a grade of zero will be assigned. Lab reports will Not be accepted from students who did not attend a lab session. Lectures will involve in-class assignments that are to be submitted through D2L. ** Laboratory attendance and lecture attendance are both mandatory. Attendance will be taken within the first 15min of the lecture / lab start time. Late admission will not count towards one's attendance grade. The TAs are responsible for managing all quizzes and labs; kindly direct any related inquiries to them. | ||||||||||||||||
| Other Information | Lecture Time: Mondays 9AM -12PM, Location: DCC 350 | ||||||||||||||||
Week | Hours | Chapters / | Topic, description |
|---|---|---|---|
1 | 3 | part I: 1 | Lecture topics: Introduction to systems and modeling and physiological signals and |
2 | 3 | part I: 4 | Lecture topics: Review of frequency decomposition of signals. Fourier series, Fourier Transform (discrete-time discrete fast short-time), wavelet transform, Laplace transform, filtering |
3 | 3 | part I: 1-2 | Lecture topics: Differential equations and numerical methods, Modeling of the cardio-respiratory system |
4 | 3 | part I: 5, part II:1 | Lecture topics: Modelling nerve action potentials, Stimulation of excitable tissue, Windkessel model |
5 | 3 | part I: 3,8, part II:3 | Lecture topics: Feedback systems, control systems, system stability, sensory receptors |
6 | 3 | part II: 8 | Lecture topics: Model validation, FEM, Immune System |
7 | 3 | part II: 7 | Lecture topics: Linear model of blood flow, mechanical and electrical analogies |
8 | 1 | Lecture topics: Review for midterm exam (material from weeks 1-6) | |
8 | 2 | (supplement) | Lecture topics: Modelling healthy and diseased ocular system |
9 | 3 | Midterm exam (in class, closed book) | |
10 | 3 | (supplemental lecture notes) | Lecture topics: Computational modelling of placental vasculature |
11 | 3 | part II: 4 | Lecture topics: Modelling skeletal muscle contraction |
12 | 3 | part II: 4-5 | Lecture topics: Modelling skeletal muscle contraction, Myoelectric activity |
13 | 3 | part II: 5-6 | Lecture topics: EMG data acquisition and processing |
14 | 3 | (supplement) | Practice modelling a variety of physiological systems: Cellular iron regulation, fructose intolerance (through an exam mock-up) |
Week | L/T/A | Description |
|---|---|---|
2-3 | 1 | Lab 1: Wavelet transformation applied to EEG |
4 | T1 | Tutorial 1: Introduction to Simulink |
5,6 | 3 | Lab 2: Windkessel model of blood circulation |
7 | T2 | Tutorial 2: Review of course concepts problem solving |
8-9 | T1 | Lab 3: System Identification |
10-11 | 4 | Lab 4: Immune System |
12 | T3 | Tutorial 3: Skeletal Muscles |
13 | T4 | Tutorial 4: Real-time data acquisition and signal processing |
Students are reminded that they are required to adhere to all relevant university policies found in their online course shell in D2L and/or on the Senate website
Refer to the Departmental FAQ page for furhter information on common questions.
You can submit an Academic Consideration Request when an extenuating circumstance has occurred that has significantly impacted your ability to fulfill an academic requirement. You may always visit the Senate website and select the blue radio button on the top right hand side entitled: Academic Consideration Request (ACR) to submit this request.
For Extenuating Circumstances, Policy 167: Academic Consideration allows for a once per semester ACR request without supporting documentation if the absence is less than 3 days in duration and is not for a final exam/final assessment. Absences more than 3 days in duration and those that involve a final exam/final assessment, require documentation. Students must notify their instructor once a request for academic consideration is submitted. See Senate Policy 167: Academic Consideration.
If a student is requesting accommodation due to a religious, Aboriginal and/or spiritual observance, they must submit their request via the online Academic Consideration Request (ACR) system within the first two weeks of the class or, for a final examination, within two weeks of the posting of the examination schedule. If the required absence occurs within the first two weeks of classes, or the dates are not known well in advance as they are linked to other conditions, these requests should be submitted with as much lead time as possible in advance of the required absence.
Academic Accommodation Support (AAS) is the university's disability services office. AAS works directly with incoming and returning students looking for help with their academic accommodations. AAS works with any student who requires academic accommodation regardless of program or course load.
Academic Accommodations (for students with disabilities) and Academic Consideration (for students faced with extenuating circumstances that can include short-term health issues) are governed by two different university policies. Learn more about Academic Accommodations versus Academic Consideration and how to access each.
At Toronto Metropolitan University, we recognize that things can come up throughout the term that may interfere with a student’s ability to succeed in their coursework. These circumstances are outside of one’s control and can have a serious impact on physical and mental well-being. Seeking help can be a challenge, especially in those times of crisis.
If you are experiencing a mental health crisis, please call 911 and go to the nearest hospital emergency room. You can also access these outside resources at anytime:
If non-crisis support is needed, you can access these campus resources:
We encourage all Toronto Metropolitan University community members to access available resources to ensure support is reachable. You can find more resources available through the Toronto Metropolitan University Mental Health and Wellbeing website.